Drugs like clonidine and nortriptyline have been applied to smoking cessation with varying levels of success. These medications generally have more severe side-effects than Chantix or Zyban, and are considered 'second-line defenses'. So far, only Zyban/Wellbutrin, Chantix/Champix, and NRT's (nicotine patch, losenge, gum, inhaler, nasal spray) have been evaluated or approved by the FDA for safe use in smoking cessation.
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