Place the lozenge into your mouth, sucking on it as you move it from side to side until it completely dissolves. Do NOT chew on the lozenge or bite down to break it. Each lozenge will last about 20-30 minutes, and nicotine will continue to absorb through the lining of the mouth for a short time after the lozenge has disappeared.
Source: Nicotine Polacrilex in Micromedex Healthcare Series, Vol 117. Thomson Micromedex 12/2002